Atovaquone and Proguanil
Comprehensive clinical interaction and dietary monograph for Atovaquone and Proguanil (Atovaquone and Proguanil).
Kitchen Food, Drink & Dietary Conflicts
Biochemical interactions with common foods, beverages & cooking ingredientsDairy Milk, Yogurt & Calcium-Enriched Foods
Divalent calcium binds fluoroquinolone (ciprofloxacin) and tetracycline (doxycycline) antibiotics into unabsorbable ring complexes, reducing systemic antibacterial coverage by up to 90% and causing therapy failure.
Prescription & OTC Drug Interactions (DDI)
Documented pharmacological conflicts & contraindicated co-prescriptionsDietary Supplements, Herbs & Minerals (DNI)
Interactions with over-the-counter vitamins, minerals, and herbal preparationsChronotherapy & Meal Administration Protocols
Optimal absorption, meal-timing rules & GI tolerability protocolsTo treat malaria, take once a day with food or a milky drink for 3 days in a row.
Rationale: Food enhances bioavailability, prevents gastric mucosal irritation, or stabilizes peak-to-trough pharmacokinetic variations.
To prevent malaria, it is taken once a daily with food or a milky drink starting 1 or 2 days before you travel to an area where malaria is common, while you are traveling, and for 7 days after you return.
Rationale: Food enhances bioavailability, prevents gastric mucosal irritation, or stabilizes peak-to-trough pharmacokinetic variations.
Taking Atovaquone and Proguanil alongside daily coffee, supplements, or other medications?
Add all your daily medications, foods (Dairy, Spinach, Coffee, Grapefruit), and botanicals (Ashwagandha, Curcumin, Melatonin) into the SafeStack interactive engine to run full multi-way synergy collision analysis in real time.
Data on this clinical monograph is compiled from the U.S. National Library of Medicine (MedlinePlus), openFDA Structured Product Labeling (SPL Section 7 Drug Interactions), the NIH Office of Dietary Supplements (ODS), and Krause and Mahan's Food & Nutrition Care Process.