Dextromethorphan

Comprehensive clinical interaction and dietary monograph for Dextromethorphan (Dextromethorphan).

Generic Active Chemical: Dextromethorphan

Brand Formulations:Delsym 12-hour CoughRobitussin Cough Long-ActingTriaminic Long-Acting CoughVicks DayQuil CoughAlka-Seltzer Plus Cold and Cough Formula (containing Aspirin, Chlorpheniramine, Dextromethorphan, Phenylephrine)Alka-Seltzer Plus Day and Night Cold Formulas (containing Aspirin, Dextromethorphan, Phenylephrine)Alka-Seltzer Plus Day Non-Drowsy Cold Formula (containing Acetaminophen, Dextromethorphan, Phenylephrine)Alka-Seltzer Plus Flu Formula (containing Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylephrine)Alka-Seltzer Plus Mucus and Congestion (containing Dextromethorphan, Guaifenesin)Alka-Seltzer Plus Night Cold Formula (containing Aspirin, Dextromethorphan, Doxylamine, Phenylephrine)Children's Dimetapp Cold and Cough (containing Brompheniramine, Dextromethorphan, Phenylephrine)Children's Dimetapp Multisymptom Cold and Flu (containing Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylephrine)Children's Mucinex Cough (containing Dextromethorphan, Guaifenesin)Children's Mucinex Multi-Symptom Cold (containing Dextromethorphan, Guaifenesin, Phenylephrine)Children's Robitussin Cough and Cold CF (containing Dextromethorphan, Guaifenesin, Phenylephrine)Children's Robitussin Cough and Cold Long-Acting (containing Chlorpheniramine, Dextromethorphan)Children's Sudafed PE Cold and Cough (containing Dextromethorphan, Phenylephrine)Coricidin HBP Chest Congestion and Cough (containing Dextromethorphan, Guaifenesin)Coricidin HBP Cough and Cold (containing Chlorpheniramine, Dextromethorphan)Coricidin HBP Day and Night Multi-Symptom Cold (containing Acetaminophen, Chlorpheniramine, Dextromethorphan, Guaifenesin)Coricidin HBP Maximum Strength Flu (containing Acetaminophen, Chlorpheniramine, Dextromethorphan)Coricidin HBP Nighttime Multi-Symptom Cold (containing Acetaminophen, Dextromethorphan, Doxylamine)Diabetic Tussin DM (containing Dextromethorphan, Guaifenesin)Dimetane DX (containing Brompheniramine, Dextromethorphan, Pseudoephedrine)Mucinex Cough for Kids (containing Dextromethorphan, Guaifenesin)Mucinex DM (containing Dextromethorphan, Guaifenesin)PediaCare Children's Cough and Congestion (containing Dextromethorphan, Guaifenesin)PediaCare Children's Fever Reducer Plus Cough and Runny Nose (containing Acetaminophen, Chlorpheniramine, Dextromethorphan)PediaCare Children's Fever Reducer Plus Cough and Sore Throat (containing Acetaminophen, Dextromethorphan)PediaCare Children's Fever Reducer Plus Flu (containing Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylephrine)PediaCare Children's Fever Reducer Plus Multi-Symptom Cold (containing Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylephrine)Robitussin Cough and Chest DM (containing Dextromethorphan, Guaifenesin)Robitussin Cough and Cold CF (containing Dextromethorphan, Guaifenesin, Phenylephrine)Robitussin Cough and Cold Long-Acting (containing Chlorpheniramine, Dextromethorphan)Robitussin Night Time Cough, Cold, and Flu (containing Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylephrine)Sudafed PE Cold/Cough (containing Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine)Sudafed PE Day/Night Cold (containing Acetaminophen, Dextromethorphan, Diphenhydramine, Guaifenesin, Phenylephrine)Theraflu Cold and Cough (containing Dextromethorphan, Pheniramine, Phenylephrine)Theraflu Daytime Severe Cold and Cough (containing Acetaminophen, Dextromethorphan, Phenylephrine)Theraflu Max-D Severe Cold and Flu (containing Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine)Triaminic Cough and Sore Throat (containing Acetaminophen, Dextromethorphan)Triaminic Day Time Cold and Cough (containing Dextromethorphan, Phenylephrine)Triaminic Multi-Symptom Fever (containing Acetaminophen, Chlorpheniramine, Dextromethorphan)Tussin DM (containing Dextromethorphan, Guaifenesin)Tylenol Cold and Cough Daytime (containing Acetaminophen, Dextromethorphan)Tylenol Cold and Cough Nighttime (containing Acetaminophen, Dextromethorphan, Doxylamine)Tylenol Cold and Flu Severe (containing Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine)Tylenol Cold Multi-Symptom Nighttime (containing Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylephrine)Tylenol Cold and Mucus Severe (containing Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine)Vicks Children's NyQuil Cold and Cough (containing Chlorpheniramine, Dextromethorphan)Vicks DayQuil Cold and Flu Relief (containing Acetaminophen, Dextromethorphan, Phenylephrine)Vicks DayQuil Cold and Flu Symptom Relief Plus Vitamin C (containing Acetaminophen, Dextromethorphan, Phenylephrine)Vicks DayQuil Mucus Control DM (containing Dextromethorphan, Guaifenesin)

Quick Jump:Kitchen Foods (0)Drug Red Flags (1)Supplements & Herbs (0)Administration Timing (0)Pairwise Combos (1)

Kitchen Food, Drink & Dietary Conflicts

Biochemical interactions with common foods, beverages & cooking ingredients

0 Flagged Foods

Unless your physician explicitly directs otherwise, continue your normal balanced diet while taking this medication. Maintain consistent hydration and meal intervals.

Prescription & OTC Drug Interactions (DDI)

Documented pharmacological conflicts & contraindicated co-prescriptions

1 Warning Classes

HIGH RISK

NSAIDs (Ibuprofen, Naproxen) & Non-Cardioprotective Analgesics

openFDA SPL Section 7 (Drug Interactions)

Mechanism: Inhibition of renal vasodilatory prostaglandins (PGI2, PGE2) causes afferent arteriolar vasoconstriction, blunts blood pressure control, and increases risk of acute kidney injury (AKI).

Clinical Consequence: Loss of blood pressure reduction, fluid retention, or acute renal hemodynamic compromise.

Physician Precaution: Consult your physician before taking OTC pain relievers. Acetaminophen may be preferred for occasional pain depending on liver status.

Dietary Supplements, Herbs & Minerals (DNI)

Interactions with over-the-counter vitamins, minerals, and herbal preparations

0 Monitored

No acute supplement or herb contraindications identified. Notify your healthcare provider of any multi-vitamins or botanicals you take daily.

Chronotherapy & Meal Administration Protocols

Optimal absorption, meal-timing rules & GI tolerability protocols

0 Protocols

Frequently Researched Drug-Substance Combinations

Explore pairwise interaction dossiers and laboratory safety analyses

HIGH→

Dextromethorphan and Aspirin / NSAIDs

Pairwise Clinical Analysis & Safety Rating

Multi-Substance Interactive Radar

Taking Dextromethorphan alongside daily coffee, supplements, or other medications?

Add all your daily medications, foods (Dairy, Spinach, Coffee, Grapefruit), and botanicals (Ashwagandha, Curcumin, Melatonin) into the SafeStack interactive engine to run full multi-way synergy collision analysis in real time.

Launch SafeStack Radar with Dextromethorphan→

Authoritative Clinical Evidence & Regulatory Sources

Data on this clinical monograph is compiled from the U.S. National Library of Medicine (MedlinePlus), openFDA Structured Product Labeling (SPL Section 7 Drug Interactions), the NIH Office of Dietary Supplements (ODS), and Krause and Mahan's Food & Nutrition Care Process.

View Original NLM MedlinePlus Monograph·Clinical & Legal Disclaimers