Enalapril and Hydrochlorothiazide
ACE inhibitors suppress the conversion of angiotensin I to angiotensin II, decreasing systemic arteriolar resistance and reducing aldosterone secretion.
Kitchen Food, Drink & Dietary Conflicts
Biochemical interactions with common foods, beverages & cooking ingredientsTalk to your doctor before using salt substitutes containing potassium. If your doctor prescribes a low-salt or low-sodium diet, follow these directions carefully.
Potassium-Enriched Salt Substitutes (Low-Sodium Table Salt)
Provides 500-1400 mg potassium per 1/4 teaspoon. When renal potassium excretion is suppressed by ACE inhibitors, ARBs, or aldosterone antagonists (spironolactone), acute severe hyperkalemia (>6.5 mEq/L) can trigger sudden flaccid paralysis and fatal ventricular fibrillation.
Alcoholic Beverages (Beer, Wine, Spirits)
Multiplies respiratory depression and profound sedation with opioids and sedatives; blocks hepatic lactate uptake with metformin (lactic acidosis); triggers acute disulfiram-like vomiting and tachycardia with metronidazole; and accelerates dose-dumping in extended-release capsules.
Prescription & OTC Drug Interactions (DDI)
Documented pharmacological conflicts & contraindicated co-prescriptionsNSAIDs (Ibuprofen, Naproxen) & Non-Cardioprotective Analgesics
Mechanism: Inhibition of renal vasodilatory prostaglandins (PGI2, PGE2) causes afferent arteriolar vasoconstriction, blunts blood pressure control, and increases risk of acute kidney injury (AKI).
Dietary Supplements, Herbs & Minerals (DNI)
Interactions with over-the-counter vitamins, minerals, and herbal preparationsPotassium Supplements (Potassium Chloride, Gluconate, Citrate)
Direct renin inhibition suppresses downstream aldosterone secretion, preventing physiological urinary potassium excretion. Exogenous potassium supplements directly provoke dangerous serum hyperkalemia.
Chronotherapy & Meal Administration Protocols
Optimal absorption, meal-timing rules & GI tolerability protocolsFrequently Researched Drug-Substance Combinations
Explore pairwise interaction dossiers and laboratory safety analysesEnalapril and Hydrochlorothiazide and Potassium
Pairwise Clinical Analysis & Safety RatingEnalapril and Hydrochlorothiazide and Salt-substitute
Pairwise Clinical Analysis & Safety RatingEnalapril and Hydrochlorothiazide and Potassium Salt Substitutes
Pairwise Clinical Analysis & Safety RatingEnalapril and Hydrochlorothiazide and Aspirin / NSAIDs
Pairwise Clinical Analysis & Safety RatingEnalapril and Hydrochlorothiazide and Alcoholic Beverages
Pairwise Clinical Analysis & Safety RatingTaking Enalapril and Hydrochlorothiazide alongside daily coffee, supplements, or other medications?
Add all your daily medications, foods (Dairy, Spinach, Coffee, Grapefruit), and botanicals (Ashwagandha, Curcumin, Melatonin) into the SafeStack interactive engine to run full multi-way synergy collision analysis in real time.
Data on this clinical monograph is compiled from the U.S. National Library of Medicine (MedlinePlus), openFDA Structured Product Labeling (SPL Section 7 Drug Interactions), the NIH Office of Dietary Supplements (ODS), and Krause and Mahan's Food & Nutrition Care Process.