Enasidenib

Comprehensive clinical interaction and dietary monograph for Enasidenib (Enasidenib).

Generic Active Chemical: Enasidenib

Brand Formulations:Idhifa

Quick Jump:Kitchen Foods (1)Drug Red Flags (0)Supplements & Herbs (0)Administration Timing (0)

Kitchen Food, Drink & Dietary Conflicts

Biochemical interactions with common foods, beverages & cooking ingredients

1 Flagged Foods

Official Patient Dietary Instruction (NLM MedlinePlus)

Drink plenty of water or other fluids every day during your treatment with enasidenib, Unless your doctor tells you otherwise, continue your normal diet.

HIGH

Coffee & High-Caffeine Beverages (Espresso, Energy Drinks)

NutriDive Kitchen Food Biochemical Ontology & openFDA

Bioactive Compound:1,3,7-Trimethylxanthine (Caffeine)

Biological Target:Cytochrome P450 1A2 (CYP1A2) & Adenosine A1/A2A Receptors

Clinical Mechanism:

Ciprofloxacin, fluvoxamine, and oral contraceptives inhibit CYP1A2, reducing caffeine clearance by 30-80% and precipitating palpitations, panic, and severe tremors. Caffeine also accelerates gastric motility, impairing bisphosphonate and thyroid absorption.

Patient Actionable Rule:Take thyroid hormones and bisphosphonates with pure plain water only. Moderate or avoid concentrated caffeine during ciprofloxacin therapy.

Prescription & OTC Drug Interactions (DDI)

Documented pharmacological conflicts & contraindicated co-prescriptions

0 Warning Classes

No major contraindicated drug classes listed in the basic monograph. Always provide your complete medication list to your prescribing physician.

Dietary Supplements, Herbs & Minerals (DNI)

Interactions with over-the-counter vitamins, minerals, and herbal preparations

0 Monitored

No acute supplement or herb contraindications identified. Notify your healthcare provider of any multi-vitamins or botanicals you take daily.

Chronotherapy & Meal Administration Protocols

Optimal absorption, meal-timing rules & GI tolerability protocols

0 Protocols

Multi-Substance Interactive Radar

Taking Enasidenib alongside daily coffee, supplements, or other medications?

Add all your daily medications, foods (Dairy, Spinach, Coffee, Grapefruit), and botanicals (Ashwagandha, Curcumin, Melatonin) into the SafeStack interactive engine to run full multi-way synergy collision analysis in real time.

Launch SafeStack Radar with Enasidenib→

Authoritative Clinical Evidence & Regulatory Sources

Data on this clinical monograph is compiled from the U.S. National Library of Medicine (MedlinePlus), openFDA Structured Product Labeling (SPL Section 7 Drug Interactions), the NIH Office of Dietary Supplements (ODS), and Krause and Mahan's Food & Nutrition Care Process.

View Original NLM MedlinePlus Monograph·Clinical & Legal Disclaimers