Prescription Clinical MonographPrescription Therapeutic Agent

Verified Evidence Sources: openFDA & NLM MedlinePlus

Estradiol Transdermal Patch

Comprehensive clinical interaction and dietary monograph for Estradiol Transdermal Patch (Estradiol Transdermal Patch).

Generic Active Chemical: Estradiol Transdermal Patch

Brand Formulations:Alora¶ClimaraEsclim¶Estraderm¶FemPatch¶MenostarMinivelleVivelle¶Vivelle-Dot

Quick Jump:Kitchen Foods (2)Drug Red Flags (0)Supplements & Herbs (0)Administration Timing (0)Pairwise Combos (3)

Kitchen Food, Drink & Dietary Conflicts

Biochemical interactions with common foods, beverages & cooking ingredients

2 Flagged Foods

Official Patient Dietary Instruction (NLM MedlinePlus)

Talk to your doctor about eating grapefruit and drinking grapefruit juice while using this medication. Talk to your doctor about ways to increase the amount of calcium and vitamin D in your diet.

CRITICAL

Grapefruit / Pomelo (Citrus paradisi / Citrus maxima)

NutriDive Kitchen Food Biochemical Ontology & openFDA

Bioactive Compound:Furanocoumarins (Bergamottin, 6',7'-Dihydroxybergamottin)

Biological Target:Intestinal Cytochrome P450 3A4 (CYP3A4) & P-glycoprotein

Clinical Mechanism:

Destroys enterocyte CYP3A4 enzymes, collapsing first-pass drug metabolism and causing up to 12-fold spikes in bioavailability for oral CYP3A4 substrates (statins, calcium channel blockers, immunosuppressants, PDE5 inhibitors).

Patient Actionable Rule:Completely avoid grapefruit, pomelos, and Seville oranges for the entire duration of therapy. Normal intestinal CYP3A4 enzyme turnover takes up to 72 hours to regenerate after ingestion.

HIGH

Fresh Orange Juice & Apple Juice (OATP Influx Blockers)

NutriDive Kitchen Food Biochemical Ontology & openFDA

Bioactive Compound:Flavonoid Glycosides (Naringin, Hesperidin)

Biological Target:Organic Anion Transporting Polypeptides (OATP1A2 & OATP2B1)

Clinical Mechanism:

Unlike CYP3A4 inhibitors that increase drug levels, fruit juice bioflavonoids block the enterocyte OATP influx pumps, plummeting absorption of oral fexofenadine (Allegra), ciprofloxacin, and atenolol by 30-70%.

Patient Actionable Rule:Take fexofenadine (Allegra) and atenolol with plain water only. Avoid drinking fruit juices within 4 hours before or after dosage.

Prescription & OTC Drug Interactions (DDI)

Documented pharmacological conflicts & contraindicated co-prescriptions

0 Warning Classes

No major contraindicated drug classes listed in the basic monograph. Always provide your complete medication list to your prescribing physician.

Dietary Supplements, Herbs & Minerals (DNI)

Interactions with over-the-counter vitamins, minerals, and herbal preparations

0 Monitored

No acute supplement or herb contraindications identified. Notify your healthcare provider of any multi-vitamins or botanicals you take daily.

Chronotherapy & Meal Administration Protocols

Optimal absorption, meal-timing rules & GI tolerability protocols

0 Protocols

Frequently Researched Drug-Substance Combinations

Explore pairwise interaction dossiers and laboratory safety analyses

HIGH→

Multi-Substance Interactive Radar

Taking Estradiol Transdermal Patch alongside daily coffee, supplements, or other medications?

Add all your daily medications, foods (Dairy, Spinach, Coffee, Grapefruit), and botanicals (Ashwagandha, Curcumin, Melatonin) into the SafeStack interactive engine to run full multi-way synergy collision analysis in real time.

Launch SafeStack Radar with Estradiol Transdermal Patch→

Authoritative Clinical Evidence & Regulatory Sources

Data on this clinical monograph is compiled from the U.S. National Library of Medicine (MedlinePlus), openFDA Structured Product Labeling (SPL Section 7 Drug Interactions), the NIH Office of Dietary Supplements (ODS), and Krause and Mahan's Food & Nutrition Care Process.

View Original NLM MedlinePlus Monograph·Clinical & Legal Disclaimers