Gabapentin

Comprehensive clinical interaction and dietary monograph for Gabapentin (Gabapentin).

Generic Active Chemical: Gabapentin

Brand Formulations:GraliseHorizantNeurontin

Quick Jump:Kitchen Foods (1)Drug Red Flags (0)Supplements & Herbs (0)Administration Timing (2)Pairwise Combos (1)

Kitchen Food, Drink & Dietary Conflicts

Biochemical interactions with common foods, beverages & cooking ingredients

1 Flagged Foods

HIGH

Alcoholic Beverages (Beer, Wine, Spirits)

NutriDive Kitchen Food Biochemical Ontology & openFDA

Bioactive Compound:Ethanol

Biological Target:GABA-A Receptors, Hepatic CYP2E1 & Gluconeogenesis

Clinical Mechanism:

Multiplies respiratory depression and profound sedation with opioids and sedatives; blocks hepatic lactate uptake with metformin (lactic acidosis); triggers acute disulfiram-like vomiting and tachycardia with metronidazole; and accelerates dose-dumping in extended-release capsules.

Patient Actionable Rule:Completely abstain from alcohol while taking metronidazole, cephalosporins, prescription sedatives, or empty-stomach metformin.

Prescription & OTC Drug Interactions (DDI)

Documented pharmacological conflicts & contraindicated co-prescriptions

0 Warning Classes

No major contraindicated drug classes listed in the basic monograph. Always provide your complete medication list to your prescribing physician.

Dietary Supplements, Herbs & Minerals (DNI)

Interactions with over-the-counter vitamins, minerals, and herbal preparations

0 Monitored

No acute supplement or herb contraindications identified. Notify your healthcare provider of any multi-vitamins or botanicals you take daily.

Chronotherapy & Meal Administration Protocols

Optimal absorption, meal-timing rules & GI tolerability protocols

2 Protocols

EMPTY_STOMACHEmpty Stomach Protocol

Gabapentin capsules, tablets, and oral solution are usually taken with a full glass of water (8 ounces [240 milliliters]), with or without food, three times a day.

Rationale: Food constituents interfere with gastrointestinal absorption or gastric emptying.

MEALMealtime Administration

The extended-release tablet (Horizant) is taken with food once daily at about 5 PM.

Rationale: Food enhances bioavailability, prevents gastric mucosal irritation, or stabilizes peak-to-trough pharmacokinetic variations.

Frequently Researched Drug-Substance Combinations

Explore pairwise interaction dossiers and laboratory safety analyses

HIGH→

Gabapentin and Alcoholic Beverages

Pairwise Clinical Analysis & Safety Rating

Multi-Substance Interactive Radar

Taking Gabapentin alongside daily coffee, supplements, or other medications?

Add all your daily medications, foods (Dairy, Spinach, Coffee, Grapefruit), and botanicals (Ashwagandha, Curcumin, Melatonin) into the SafeStack interactive engine to run full multi-way synergy collision analysis in real time.

Launch SafeStack Radar with Gabapentin→

Authoritative Clinical Evidence & Regulatory Sources

Data on this clinical monograph is compiled from the U.S. National Library of Medicine (MedlinePlus), openFDA Structured Product Labeling (SPL Section 7 Drug Interactions), the NIH Office of Dietary Supplements (ODS), and Krause and Mahan's Food & Nutrition Care Process.

View Original NLM MedlinePlus Monograph·Clinical & Legal Disclaimers