Imipenem and Cilastatin Injection

Statins competitively inhibit 3-hydroxy-3-methylglutaryl-coenzyme A reductase, the rate-limiting enzyme in hepatic cholesterol biosynthesis.

Generic Active Chemical: Imipenem and Cilastatin Injection

Brand Formulations:Primaxin (containing Cilastatin, Imipenem)

Quick Jump:Kitchen Foods (0)Drug Red Flags (0)Supplements & Herbs (1)Nutrient Depletion (1)Administration Timing (0)

Kitchen Food, Drink & Dietary Conflicts

Biochemical interactions with common foods, beverages & cooking ingredients

0 Flagged Foods

Unless your physician explicitly directs otherwise, continue your normal balanced diet while taking this medication. Maintain consistent hydration and meal intervals.

Prescription & OTC Drug Interactions (DDI)

Documented pharmacological conflicts & contraindicated co-prescriptions

0 Warning Classes

No major contraindicated drug classes listed in the basic monograph. Always provide your complete medication list to your prescribing physician.

Dietary Supplements, Herbs & Minerals (DNI)

Interactions with over-the-counter vitamins, minerals, and herbal preparations

1 Monitored

HIGH

St. John's Wort (Hypericum perforatum)

NIH National Center for Complementary and Integrative Health (NCCIH)

Biological Target: Hepatic Cytochrome P450 3A4 / 2C9 & P-glycoprotein (P-gp)

Hyperforin potently activates the Pregnane X Receptor (PXR), inducing hepatic CYP enzymes and intestinal P-gp pumps. This accelerates medication clearance and precipitates therapeutic failure.

Guidance & Spacing:Completely avoid herbal St. John's Wort while taking prescription medications.

Drug-Induced Nutrient Depletion & Nutritional Defense

Micronutrient depletions caused by pharmacological pathways & recommended replenishment

1 Depletion Pathways

Coenzyme Q10 (Ubiquinone / CoQ10)

Krause and Mahan's Food & Nutrition Care Process

Depletion Pathway: Statins competitively inhibit HMG-CoA reductase, blocking synthesis of mevalonate—an essential shared precursor for endogenous ubiquinone production.

Nutritional Defense Protocol:Consider 100–200 mg daily of CoQ10 (Ubiquinol form) taken with fat-containing meals if experiencing muscle fatigue or statin-associated myalgias (SAMS).

Chronotherapy & Meal Administration Protocols

Optimal absorption, meal-timing rules & GI tolerability protocols

0 Protocols

Multi-Substance Interactive Radar

Taking Imipenem and Cilastatin Injection alongside daily coffee, supplements, or other medications?

Add all your daily medications, foods (Dairy, Spinach, Coffee, Grapefruit), and botanicals (Ashwagandha, Curcumin, Melatonin) into the SafeStack interactive engine to run full multi-way synergy collision analysis in real time.

Launch SafeStack Radar with Imipenem and Cilastatin Injection→

Authoritative Clinical Evidence & Regulatory Sources

Data on this clinical monograph is compiled from the U.S. National Library of Medicine (MedlinePlus), openFDA Structured Product Labeling (SPL Section 7 Drug Interactions), the NIH Office of Dietary Supplements (ODS), and Krause and Mahan's Food & Nutrition Care Process.

View Original NLM MedlinePlus Monograph·Clinical & Legal Disclaimers