Prescription Clinical MonographPrescription Therapeutic Agent
Verified Evidence Sources: openFDA & NLM MedlinePlus

Iron Supplements

Comprehensive clinical interaction and dietary monograph for Iron Supplements (Iron Supplements).

Generic Active Chemical: Iron Supplements
Brand Formulations:FeosolFer-in-SolFerra-TD¶HemocytePureFe PlusSlow-FeNiferex(as a combination product containing Ferrous Asparto Glycinate, Iron, Ascorbic Acid, Folic Acid, Cyanocobalamin, Zinc, and Succinic Acid)Folvron (containing Ferrous Sulfate, Folic Acid)¶

Kitchen Food, Drink & Dietary Conflicts

Biochemical interactions with common foods, beverages & cooking ingredients
2 Flagged Foods
HIGH

Dairy Milk, Yogurt & Calcium-Enriched Foods

NutriDive Kitchen Food Biochemical Ontology & openFDA
Bioactive Compound:Ionic Calcium (Ca2+) & Casein Micelles
Biological Target:Intestinal Chelation & Luminal Complexation
Clinical Mechanism:

Divalent calcium binds fluoroquinolone (ciprofloxacin) and tetracycline (doxycycline) antibiotics into unabsorbable ring complexes, reducing systemic antibacterial coverage by up to 90% and causing therapy failure.

Patient Actionable Rule:Separate all dairy ingestion from oral antibiotics, bisphosphonates, and thyroid medications by at least 2 to 4 hours.
HIGH

Alcoholic Beverages (Beer, Wine, Spirits)

NutriDive Kitchen Food Biochemical Ontology & openFDA
Bioactive Compound:Ethanol
Biological Target:GABA-A Receptors, Hepatic CYP2E1 & Gluconeogenesis
Clinical Mechanism:

Multiplies respiratory depression and profound sedation with opioids and sedatives; blocks hepatic lactate uptake with metformin (lactic acidosis); triggers acute disulfiram-like vomiting and tachycardia with metronidazole; and accelerates dose-dumping in extended-release capsules.

Patient Actionable Rule:Completely abstain from alcohol while taking metronidazole, cephalosporins, prescription sedatives, or empty-stomach metformin.

Prescription & OTC Drug Interactions (DDI)

Documented pharmacological conflicts & contraindicated co-prescriptions
0 Warning Classes
No major contraindicated drug classes listed in the basic monograph. Always provide your complete medication list to your prescribing physician.

Dietary Supplements, Herbs & Minerals (DNI)

Interactions with over-the-counter vitamins, minerals, and herbal preparations
0 Monitored
No acute supplement or herb contraindications identified. Notify your healthcare provider of any multi-vitamins or botanicals you take daily.

Chronotherapy & Meal Administration Protocols

Optimal absorption, meal-timing rules & GI tolerability protocols
2 Protocols
MEALMealtime Administration

Iron is usually taken with food or immediately after a meal once daily or as directed by your doctor.

Rationale: Food enhances bioavailability, prevents gastric mucosal irritation, or stabilizes peak-to-trough pharmacokinetic variations.

MEALAdministration Rule

Mix the elixir with water or fruit juice to avoid possible teeth staining; do not mix with milk or wine-based solutions.

Rationale: Promotes optimal mucosal absorption and consistent therapeutic plasma levels.

Multi-Substance Interactive Radar

Taking Iron Supplements alongside daily coffee, supplements, or other medications?

Add all your daily medications, foods (Dairy, Spinach, Coffee, Grapefruit), and botanicals (Ashwagandha, Curcumin, Melatonin) into the SafeStack interactive engine to run full multi-way synergy collision analysis in real time.

Launch SafeStack Radar with Iron Supplements→
Authoritative Clinical Evidence & Regulatory Sources

Data on this clinical monograph is compiled from the U.S. National Library of Medicine (MedlinePlus), openFDA Structured Product Labeling (SPL Section 7 Drug Interactions), the NIH Office of Dietary Supplements (ODS), and Krause and Mahan's Food & Nutrition Care Process.