Isotretinoin

Comprehensive clinical interaction and dietary monograph for Isotretinoin (Isotretinoin).

Generic Active Chemical: Isotretinoin

Brand Formulations:AbsoricaAccutane¶AmnesteemClaravisMyorisanSotret¶Zenatane

Quick Jump:Kitchen Foods (0)Drug Red Flags (0)Supplements & Herbs (1)Administration Timing (1)

Kitchen Food, Drink & Dietary Conflicts

Biochemical interactions with common foods, beverages & cooking ingredients

0 Flagged Foods

Unless your physician explicitly directs otherwise, continue your normal balanced diet while taking this medication. Maintain consistent hydration and meal intervals.

Prescription & OTC Drug Interactions (DDI)

Documented pharmacological conflicts & contraindicated co-prescriptions

0 Warning Classes

No major contraindicated drug classes listed in the basic monograph. Always provide your complete medication list to your prescribing physician.

Dietary Supplements, Herbs & Minerals (DNI)

Interactions with over-the-counter vitamins, minerals, and herbal preparations

1 Monitored

HIGH

St. John's Wort (Hypericum perforatum)

NIH National Center for Complementary and Integrative Health (NCCIH)

Biological Target: Hepatic Cytochrome P450 3A4 / 2C9 & P-glycoprotein (P-gp)

Hyperforin potently activates the Pregnane X Receptor (PXR), inducing hepatic CYP enzymes and intestinal P-gp pumps. This accelerates medication clearance and precipitates therapeutic failure.

Guidance & Spacing:Completely avoid herbal St. John's Wort while taking prescription medications.

Chronotherapy & Meal Administration Protocols

Optimal absorption, meal-timing rules & GI tolerability protocols

1 Protocols

MEALMealtime Administration

Isotretinoin is usually taken twice a day with meals for 4 to 5 months at a time.

Rationale: Food enhances bioavailability, prevents gastric mucosal irritation, or stabilizes peak-to-trough pharmacokinetic variations.

Multi-Substance Interactive Radar

Taking Isotretinoin alongside daily coffee, supplements, or other medications?

Add all your daily medications, foods (Dairy, Spinach, Coffee, Grapefruit), and botanicals (Ashwagandha, Curcumin, Melatonin) into the SafeStack interactive engine to run full multi-way synergy collision analysis in real time.

Launch SafeStack Radar with Isotretinoin→

Authoritative Clinical Evidence & Regulatory Sources

Data on this clinical monograph is compiled from the U.S. National Library of Medicine (MedlinePlus), openFDA Structured Product Labeling (SPL Section 7 Drug Interactions), the NIH Office of Dietary Supplements (ODS), and Krause and Mahan's Food & Nutrition Care Process.

View Original NLM MedlinePlus Monograph·Clinical & Legal Disclaimers