Prescription Clinical MonographAngiotensin II Receptor Blocker (ARB)

Verified Evidence Sources: openFDA & NLM MedlinePlus

Losartan

ARBs selectively block the binding of angiotensin II to the AT1 receptor subtype, blunting vasoconstriction and aldosterone release without inhibiting bradykinin degradation.

Generic Active Chemical: Losartan

Brand Formulations:CozaarHyzaar (containing Hydrochlorothiazide, Losartan)

Quick Jump:Kitchen Foods (1)Drug Red Flags (2)Supplements & Herbs (1)Administration Timing (0)Pairwise Combos (4)

Kitchen Food, Drink & Dietary Conflicts

Biochemical interactions with common foods, beverages & cooking ingredients

1 Flagged Foods

Official Patient Dietary Instruction (NLM MedlinePlus)

Do not use salt substitutes containing potassium without talking to your doctor. If your doctor prescribes a low-salt or low-sodium diet, follow these directions carefully.

CRITICAL

Potassium-Enriched Salt Substitutes (Low-Sodium Table Salt)

NutriDive Kitchen Food Biochemical Ontology & openFDA

Bioactive Compound:Potassium Chloride (KCl)

Biological Target:Renal Cortical Collecting Duct Electrophysiology

Clinical Mechanism:

Provides 500-1400 mg potassium per 1/4 teaspoon. When renal potassium excretion is suppressed by ACE inhibitors, ARBs, or aldosterone antagonists (spironolactone), acute severe hyperkalemia (>6.5 mEq/L) can trigger sudden flaccid paralysis and fatal ventricular fibrillation.

Patient Actionable Rule:Strictly verify ingredients of low-sodium seasonings. Avoid potassium-chloride based salt alternatives completely if taking Lisinopril, Losartan, or Spironolactone.

Prescription & OTC Drug Interactions (DDI)

Documented pharmacological conflicts & contraindicated co-prescriptions

2 Warning Classes

HIGH RISK

NSAIDs (Ibuprofen, Naproxen) & Non-Cardioprotective Analgesics

openFDA SPL Section 7 (Drug Interactions)

Mechanism: Inhibition of renal vasodilatory prostaglandins (PGI2, PGE2) causes afferent arteriolar vasoconstriction, blunts blood pressure control, and increases risk of acute kidney injury (AKI).

Clinical Consequence: Loss of blood pressure reduction, fluid retention, or acute renal hemodynamic compromise.

Physician Precaution: Consult your physician before taking OTC pain relievers. Acetaminophen may be preferred for occasional pain depending on liver status.

CRITICAL RISK

Dual RAAS Blockers (ACE Inhibitors, ARBs, Direct Renin Inhibitors)

FDA Drug Safety Communication & Black Box Warnings

Mechanism: Additive suppression of the renin-angiotensin-aldosterone axis produces profound systemic hypotension, acute renal dysfunction, and hyperkalemia without added cardiovascular benefit.

Clinical Consequence: Severe hypotension, syncope, and hyperkalemic cardiac events.

Physician Precaution: Concomitant use of aliskiren with ARBs or ACE inhibitors is contraindicated in patients with diabetes or moderate-to-severe renal impairment.

Dietary Supplements, Herbs & Minerals (DNI)

Interactions with over-the-counter vitamins, minerals, and herbal preparations

1 Monitored

CRITICAL

Potassium Supplements (Potassium Chloride, Gluconate, Citrate)

NIH Office of Dietary Supplements (ODS) & NLM MedlinePlus

Biological Target: Myocardial Resting Membrane Potential & Cardiac Conduction

Direct renin inhibition suppresses downstream aldosterone secretion, preventing physiological urinary potassium excretion. Exogenous potassium supplements directly provoke dangerous serum hyperkalemia.

Guidance & Spacing:Do not take oral potassium supplements unless specifically prescribed and monitored by your physician.

Chronotherapy & Meal Administration Protocols

Optimal absorption, meal-timing rules & GI tolerability protocols

0 Protocols

Frequently Researched Drug-Substance Combinations

Explore pairwise interaction dossiers and laboratory safety analyses

CRITICAL→

Multi-Substance Interactive Radar

Taking Losartan alongside daily coffee, supplements, or other medications?

Add all your daily medications, foods (Dairy, Spinach, Coffee, Grapefruit), and botanicals (Ashwagandha, Curcumin, Melatonin) into the SafeStack interactive engine to run full multi-way synergy collision analysis in real time.

Launch SafeStack Radar with Losartan→

Authoritative Clinical Evidence & Regulatory Sources

Data on this clinical monograph is compiled from the U.S. National Library of Medicine (MedlinePlus), openFDA Structured Product Labeling (SPL Section 7 Drug Interactions), the NIH Office of Dietary Supplements (ODS), and Krause and Mahan's Food & Nutrition Care Process.

View Original NLM MedlinePlus Monograph·Clinical & Legal Disclaimers