Penicillamine
Comprehensive clinical interaction and dietary monograph for Penicillamine (Penicillamine).
Kitchen Food, Drink & Dietary Conflicts
Biochemical interactions with common foods, beverages & cooking ingredientsIf you are being treated for Wilson's disease your doctor will probably recommend a special diet for you that is low in copper. This diet avoids cereals and dietary supplements that are enriched with copper, chocolate, nuts, shellfish, mushrooms, liver, molasses, broccoli, and other high copper containing foods. Your doctor may also recommend that you drink distilled or demineralized water, instead of regular tap water. Be sure to follow all dietary recommendations made by your doctor. If you are being treated for cystinuria your doctor may recommend a special diet for you that is low in methionine (a type of protein). However if you are a child or if you are pregnant your doctor may not recommend this diet. Your doctor will also probably recommend that you drink enough liquids. If you are being treated for rheumatoid arthritis, continue your normal diet unless your doctor tells you otherwise.
Green Tea, Black Tea & Matcha (Tannins & OATP Inhibitors)
Tannins form insoluble macromolecular iron-tannate precipitates, dropping non-heme iron absorption by up to 80%. Catechins additionally inhibit intestinal OATP uptake transporters, drastically reducing bioavailability of beta-blockers (atenolol) and allergy medications (fexofenadine).
Dairy Milk, Yogurt & Calcium-Enriched Foods
Divalent calcium binds fluoroquinolone (ciprofloxacin) and tetracycline (doxycycline) antibiotics into unabsorbable ring complexes, reducing systemic antibacterial coverage by up to 90% and causing therapy failure.
Prescription & OTC Drug Interactions (DDI)
Documented pharmacological conflicts & contraindicated co-prescriptionsDietary Supplements, Herbs & Minerals (DNI)
Interactions with over-the-counter vitamins, minerals, and herbal preparationsChronotherapy & Meal Administration Protocols
Optimal absorption, meal-timing rules & GI tolerability protocolsIt is usually taken on an empty stomach at least 1 hour before or 2 hours after a meal, and at least 1 hour before or after any food or milk.
Rationale: Food constituents interfere with gastrointestinal absorption or gastric emptying.
Taking Penicillamine alongside daily coffee, supplements, or other medications?
Add all your daily medications, foods (Dairy, Spinach, Coffee, Grapefruit), and botanicals (Ashwagandha, Curcumin, Melatonin) into the SafeStack interactive engine to run full multi-way synergy collision analysis in real time.
Data on this clinical monograph is compiled from the U.S. National Library of Medicine (MedlinePlus), openFDA Structured Product Labeling (SPL Section 7 Drug Interactions), the NIH Office of Dietary Supplements (ODS), and Krause and Mahan's Food & Nutrition Care Process.