Posaconazole
Comprehensive clinical interaction and dietary monograph for Posaconazole (Posaconazole).
Kitchen Food, Drink & Dietary Conflicts
Biochemical interactions with common foods, beverages & cooking ingredientsAlcoholic Beverages (Beer, Wine, Spirits)
Multiplies respiratory depression and profound sedation with opioids and sedatives; blocks hepatic lactate uptake with metformin (lactic acidosis); triggers acute disulfiram-like vomiting and tachycardia with metronidazole; and accelerates dose-dumping in extended-release capsules.
Potassium-Enriched Salt Substitutes (NoSalt, Nu-Salt)
Exogenous potassium chloride loads cannot be cleared efficiently when RAAS or renal filtration is modified, risking acute lethal hyperkalemia (>6.5 mEq/L) and ventricular arrhythmias.
Prescription & OTC Drug Interactions (DDI)
Documented pharmacological conflicts & contraindicated co-prescriptionsDietary Supplements, Herbs & Minerals (DNI)
Interactions with over-the-counter vitamins, minerals, and herbal preparationsChronotherapy & Meal Administration Protocols
Optimal absorption, meal-timing rules & GI tolerability protocolsThe delayed-release oral suspension is usually taken with food twice daily on the first day and then once a day.
Rationale: Food enhances bioavailability, prevents gastric mucosal irritation, or stabilizes peak-to-trough pharmacokinetic variations.
Take the mixture with food within 1 hour of mixing.
Rationale: Food enhances bioavailability, prevents gastric mucosal irritation, or stabilizes peak-to-trough pharmacokinetic variations.
Frequently Researched Drug-Substance Combinations
Explore pairwise interaction dossiers and laboratory safety analysesTaking Posaconazole alongside daily coffee, supplements, or other medications?
Add all your daily medications, foods (Dairy, Spinach, Coffee, Grapefruit), and botanicals (Ashwagandha, Curcumin, Melatonin) into the SafeStack interactive engine to run full multi-way synergy collision analysis in real time.
Data on this clinical monograph is compiled from the U.S. National Library of Medicine (MedlinePlus), openFDA Structured Product Labeling (SPL Section 7 Drug Interactions), the NIH Office of Dietary Supplements (ODS), and Krause and Mahan's Food & Nutrition Care Process.