Pseudoephedrine

Comprehensive clinical interaction and dietary monograph for Pseudoephedrine (Pseudoephedrine).

Generic Active Chemical: Pseudoephedrine

Brand Formulations:Afrinol¶Aprodine¶Cenafed¶Children's Sudafed Nasal DecongestantCongestaclear¶Efidac¶Myfedrine¶Pseudocot¶Ridafed¶SilfedrineSudafed 12/24 HourSudafed CongestionSudodrin¶SudoGestSudrine¶Superfed¶SuphedrinAllegra-D (as a combination product containing Fexofenadine, Pseudoephedrine)AccuHist DM (containing Brompheniramine, Dextromethorphan, Guaifenesin, Pseudoephedrine)§Advil Allergy Sinus (containing Chlorpheniramine, Ibuprofen, Pseudoephedrine)Advil Cold and Sinus (containing Ibuprofen, Pseudoephedrine)Alavert Allergy and Sinus D-12 (containing Loratadine, Pseudoephedrine)Aldex GS (containing Guaifenesin, Pseudoephedrine)Aldex GS DM (containing Dextromethorphan, Guaifenesin, Pseudoephedrine)Aleve-D Sinus and Cold (containing Naproxen, Pseudoephedrine)Allergy Relief D (containing Cetirizine, Pseudoephedrine)Ambifed (containing Guaifenesin, Pseudoephedrine)§Ambifed DM (containing Dextromethorphan, Guaifenesin, Pseudoephedrine)§Biodec DM (containing Dextromethorphan, Pseudoephedrine)§BP 8 (containing Dextromethorphan, Guaifenesin, Pseudoephedrine)§Brofed (containing Brompheniramine, Pseudoephedrine)§Bromdex (containing Brompheniramine, Dextromethorphan, Pseudoephedrine)§Bromfed (containing Brompheniramine, Pseudoephedrine)§Bromfed DM (containing Brompheniramine, Dextromethorphan, Pseudoephedrine)Bromhist DM (containing Brompheniramine, Dextromethorphan, Guaifenesin, Pseudoephedrine)§Bromphenex DM (containing Brompheniramine, Dextromethorphan, Pseudoephedrine)Bromuphed (containing Brompheniramine, Pseudoephedrine)§Bromuphed PD (containing Brompheniramine, Pseudoephedrine)§Brotapp (containing Brompheniramine, Pseudoephedrine)Brotapp-DM Cold and Cough (containing Brompheniramine, Dextromethorphan, Pseudoephedrine)Brovex PSB (containing Brompheniramine, Pseudoephedrine)Brovex PSB DM (containing Brompheniramine, Dextromethorphan, Pseudoephedrine)Brovex SR (containing Brompheniramine, Pseudoephedrine)§Carbofed DM (containing Brompheniramine, Dextromethorphan, Pseudoephedrine)§Certuss-D (containing Chlophedianol, Guaifenesin, Pseudoephedrine)Cetiri-D (containing Cetirizine, Pseudoephedrine)Children's Advil Cold (containing Ibuprofen, Pseudoephedrine)Children's Motrin Cold (containing Ibuprofen, Pseudoephedrine)Chlorfed A SR (containing Chlorpheniramine, Pseudoephedrine)§Clarinex-D (containing Desloratadine, Pseudoephedrine)Claritin-D (containing Loratadine, Pseudoephedrine)Coldamine (containing Chlorpheniramine, Methscopolamine, Pseudoephedrine)§Coldmist DM (containing Dextromethorphan, Guaifenesin, Pseudoephedrine)§Coldmist LA (containing Guaifenesin, Pseudoephedrine)§Colfed A (containing Chlorpheniramine, Pseudoephedrine)§Corzall (containing Carbetapentane, Pseudoephedrine)§Dallergy PSE (containing Chlorpheniramine, Methscopolamine, Pseudoephedrine)§Deconamine (containing Chlorpheniramine, Pseudoephedrine)§Deconomed SR (containing Chlorpheniramine, Pseudoephedrine)§Defen LA (containing Guaifenesin, Pseudoephedrine)§Dimetane DX (containing Brompheniramine, Dextromethorphan, Pseudoephedrine)Drixoral (containing Dexbrompheniramine, Pseudoephedrine)Drymax (containing Chlorpheniramine, Methscopolamine, Pseudoephedrine)§Dynahist ER (containing Chlorpheniramine, Pseudoephedrine)§EndaCof-DC (containing Codeine, Pseudoephedrine)EndaCof-PD (containing Brompheniramine, Dextromethorphan, Pseudoephedrine)§Entex PSE (containing Guaifenesin, Pseudoephedrine)§Exall D (containing Carbetapentane, Guaifenesin, Pseudoephedrine)§ExeFen DMX (containing Dextromethorphan, Guaifenesin, Pseudoephedrine)ExeFen IR (containing Guaifenesin, Pseudoephedrine)Guaidex TR (containing Chlorpheniramine, Dextromethorphan, Guaifenesin, Methscopolamine, Pseudoephedrine)§Hexafed (containing Dexchlorpheniramine, Pseudoephedrine)§Histacol DM (containing Brompheniramine, Guaifenesin, Dexchlorpheniramine, Pseudoephedrine)§Histex (containing Chlorpheniramine, Pseudoephedrine)§Lodrane (containing Brompheniramine, Pseudoephedrine)§LoHist-D (containing Chlorpheniramine, Pseudoephedrine)§LoHist-PD (containing Brompheniramine, Pseudoephedrine)§LoHist-PSB (containing Brompheniramine, Pseudoephedrine)LoHist-PSB-DM (containing Brompheniramine, Dextromethorphan, Pseudoephedrine)Lortuss DM (containing Dextromethorphan, Doxylamine, Pseudoephedrine)Lortuss EX (containing Codeine, Guaifenesin, Pseudoephedrine)Lortuss LQ (containing Doxylamine, Pseudoephedrine)Medent DM (containing Dextromethorphan, Guaifenesin, Pseudoephedrine)§Medent LD (containing Guaifenesin, Pseudoephedrine)§Mintex (containing Chlorpheniramine, Pseudoephedrine)§Mucinex D (containing Guaifenesin, Pseudoephedrine)Myphetane Dx (containing Brompheniramine, Dextromethorphan, Pseudoephedrine)§Nalex (containing Guaifenesin, Pseudoephedrine)§Nasatab LA (containing Guaifenesin, Pseudoephedrine)§Neutrahist (containing Chlorpheniramine, Pseudoephedrine)§Notuss-NXD (containing Chlorcyclizine, Codeine, Pseudoephedrine)§Pediahist DM (containing Brompheniramine, Dextromethorphan, Guaifenesin, Pseudoephedrine)§Polyvent (containing Guaifenesin, Pseudoephedrine)§Pseudodine (containing Pseudoephedrine, Triprolidine)Relcof PSE (containing Chlorpheniramine, Methscopolamine, Pseudoephedrine)§Respa 1st (containing Guaifenesin, Pseudoephedrine)§Respaire (containing Guaifenesin, Pseudoephedrine)§Respivent D (containing Chlorpheniramine, Methscopolamine, Pseudoephedrine)§Rezira (containing Hydrocodone, Pseudoephedrine)Rondamine DM (containing Dextromethorphan, Pseudoephedrine)§Rondec (containing Brompheniramine, Pseudoephedrine)§Rondec DM (containing Dextromethorphan, Pseudoephedrine)§Ru-Tuss DM (containing Dextromethorphan, Guaifenesin, Pseudoephedrine)§Semprex-D (containing Acrivastine, Pseudoephedrine)Suclor (containing Chlorpheniramine, Pseudoephedrine)§Sudafed 12 Hour Pressure/Pain (containing Naproxen, Pseudoephedrine)Sudafed Triple Action (containing Acetaminophen, Guaifenesin, Pseudoephedrine)Sudahist (containing Chlorpheniramine, Pseudoephedrine)§Sudatex DM (containing Dextromethorphan, Guaifenesin, Pseudoephedrine)§Sudatrate (containing Methscopolamine, Pseudoephedrine)§Tekral (containing Diphenhydramine, Pseudoephedrine)§Tenar DM (containing Dextromethorphan, Guaifenesin, Pseudoephedrine)§Tenar PSE (containing Guaifenesin, Pseudoephedrine)§Theraflu Max-D Severe Cold and Flu (containing Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine)Touro CC (containing Dextromethorphan, Guaifenesin, Pseudoephedrine)§Touro LA (containing Guaifenesin, Pseudoephedrine)§Triacin (containing Pseudoephedrine, Triprolidine)Trikof D (containing Dextromethorphan, Guaifenesin, Pseudoephedrine)§Trispec PSE (containing Dextromethorphan, Guaifenesin, Pseudoephedrine)§Tussafed LA (containing Dextromethorphan, Guaifenesin, Pseudoephedrine)§Tylenol Sinus Severe Congestion Daytime (containing Acetaminophen, Guaifenesin, Pseudoephedrine)Vanacof (containing Chlophedianol, Dexchlorpheniramine, Pseudoephedrine)Vanacof DX (containing Chlophedianol, Guaifenesin, Pseudoephedrine)Viravan P (containing Pseudoephedrine, Pyrilamine)§Viravan PDM (containing Dextromethorphan, Pseudoephedrine, Pyrilamine)§Z-Cof DM (containing Dextromethorphan, Guaifenesin, Pseudoephedrine)§Zodryl DEC (containing Codeine, Guaifenesin, Pseudoephedrine)Zutripro (containing Chlorpheniramine, Hydrocodone, Pseudoephedrine)Zymine DRX (containing Pseudoephedrine, Triprolidine)§Zyrtec-D (containing Cetirizine, Pseudoephedrine)

Quick Jump:Kitchen Foods (1)Drug Red Flags (1)Supplements & Herbs (0)Administration Timing (0)Pairwise Combos (1)

Kitchen Food, Drink & Dietary Conflicts

Biochemical interactions with common foods, beverages & cooking ingredients

1 Flagged Foods

Official Patient Dietary Instruction (NLM MedlinePlus)

Foods and drinks that contain large amounts of caffeine can make the side effects of pseudoephedrine worse.

HIGH

Coffee & High-Caffeine Beverages (Espresso, Energy Drinks)

NutriDive Kitchen Food Biochemical Ontology & openFDA

Bioactive Compound:1,3,7-Trimethylxanthine (Caffeine)

Biological Target:Cytochrome P450 1A2 (CYP1A2) & Adenosine A1/A2A Receptors

Clinical Mechanism:

Ciprofloxacin, fluvoxamine, and oral contraceptives inhibit CYP1A2, reducing caffeine clearance by 30-80% and precipitating palpitations, panic, and severe tremors. Caffeine also accelerates gastric motility, impairing bisphosphonate and thyroid absorption.

Patient Actionable Rule:Take thyroid hormones and bisphosphonates with pure plain water only. Moderate or avoid concentrated caffeine during ciprofloxacin therapy.

Prescription & OTC Drug Interactions (DDI)

Documented pharmacological conflicts & contraindicated co-prescriptions

1 Warning Classes

HIGH RISK

NSAIDs (Ibuprofen, Naproxen) & Non-Cardioprotective Analgesics

openFDA SPL Section 7 (Drug Interactions)

Mechanism: Inhibition of renal vasodilatory prostaglandins (PGI2, PGE2) causes afferent arteriolar vasoconstriction, blunts blood pressure control, and increases risk of acute kidney injury (AKI).

Clinical Consequence: Loss of blood pressure reduction, fluid retention, or acute renal hemodynamic compromise.

Physician Precaution: Consult your physician before taking OTC pain relievers. Acetaminophen may be preferred for occasional pain depending on liver status.

Dietary Supplements, Herbs & Minerals (DNI)

Interactions with over-the-counter vitamins, minerals, and herbal preparations

0 Monitored

No acute supplement or herb contraindications identified. Notify your healthcare provider of any multi-vitamins or botanicals you take daily.

Chronotherapy & Meal Administration Protocols

Optimal absorption, meal-timing rules & GI tolerability protocols

0 Protocols

Frequently Researched Drug-Substance Combinations

Explore pairwise interaction dossiers and laboratory safety analyses

HIGH→

Pseudoephedrine and Aspirin / NSAIDs

Pairwise Clinical Analysis & Safety Rating

Multi-Substance Interactive Radar

Taking Pseudoephedrine alongside daily coffee, supplements, or other medications?

Add all your daily medications, foods (Dairy, Spinach, Coffee, Grapefruit), and botanicals (Ashwagandha, Curcumin, Melatonin) into the SafeStack interactive engine to run full multi-way synergy collision analysis in real time.

Launch SafeStack Radar with Pseudoephedrine→

Authoritative Clinical Evidence & Regulatory Sources

Data on this clinical monograph is compiled from the U.S. National Library of Medicine (MedlinePlus), openFDA Structured Product Labeling (SPL Section 7 Drug Interactions), the NIH Office of Dietary Supplements (ODS), and Krause and Mahan's Food & Nutrition Care Process.

View Original NLM MedlinePlus Monograph·Clinical & Legal Disclaimers