Sildenafil
PDE5 inhibitors enhance cellular cyclic GMP levels by inhibiting cGMP degradation in cavernosal smooth muscle and pulmonary vascular endothelium.
Kitchen Food, Drink & Dietary Conflicts
Biochemical interactions with common foods, beverages & cooking ingredientsTalk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medicine.
Grapefruit / Pomelo (Citrus paradisi / Citrus maxima)
Destroys enterocyte CYP3A4 enzymes, collapsing first-pass drug metabolism and causing up to 12-fold spikes in bioavailability for oral CYP3A4 substrates (statins, calcium channel blockers, immunosuppressants, PDE5 inhibitors).
Fresh Orange Juice & Apple Juice (OATP Influx Blockers)
Unlike CYP3A4 inhibitors that increase drug levels, fruit juice bioflavonoids block the enterocyte OATP influx pumps, plummeting absorption of oral fexofenadine (Allegra), ciprofloxacin, and atenolol by 30-70%.
High-Fat Meals, Greasy & Fried Foods
High-fat meals substantially alter gastrointestinal transit time and micellar partitioning, decreasing peak systemic drug concentration (Cmax) by up to 71% (as seen with Aliskiren) or delaying onset.
Prescription & OTC Drug Interactions (DDI)
Documented pharmacological conflicts & contraindicated co-prescriptionsDietary Supplements, Herbs & Minerals (DNI)
Interactions with over-the-counter vitamins, minerals, and herbal preparationsChronotherapy & Meal Administration Protocols
Optimal absorption, meal-timing rules & GI tolerability protocolsFrequently Researched Drug-Substance Combinations
Explore pairwise interaction dossiers and laboratory safety analysesSildenafil and Nitroglycerin
Pairwise Clinical Analysis & Safety RatingSildenafil and Grapefruit
Pairwise Clinical Analysis & Safety RatingSildenafil and Grapefruit-juice
Pairwise Clinical Analysis & Safety RatingSildenafil and Alcohol-ethanol
Pairwise Clinical Analysis & Safety RatingSildenafil and Medlineplus-dietary-guidance
Pairwise Clinical Analysis & Safety RatingTaking Sildenafil alongside daily coffee, supplements, or other medications?
Add all your daily medications, foods (Dairy, Spinach, Coffee, Grapefruit), and botanicals (Ashwagandha, Curcumin, Melatonin) into the SafeStack interactive engine to run full multi-way synergy collision analysis in real time.
Data on this clinical monograph is compiled from the U.S. National Library of Medicine (MedlinePlus), openFDA Structured Product Labeling (SPL Section 7 Drug Interactions), the NIH Office of Dietary Supplements (ODS), and Krause and Mahan's Food & Nutrition Care Process.