Trimethoprim
Comprehensive clinical interaction and dietary monograph for Trimethoprim (Trimethoprim).
Kitchen Food, Drink & Dietary Conflicts
Biochemical interactions with common foods, beverages & cooking ingredientsTake trimethoprim on an empty stomach, 1 hour before or 2 hours after meals. However, if you experience nausea, you may take trimethoprim with food. Drink at least eight glasses of liquid (water, tea, coffee, soft drinks, milk, and fruit juice) every day.
Green Tea, Black Tea & Matcha (Tannins & OATP Inhibitors)
Tannins form insoluble macromolecular iron-tannate precipitates, dropping non-heme iron absorption by up to 80%. Catechins additionally inhibit intestinal OATP uptake transporters, drastically reducing bioavailability of beta-blockers (atenolol) and allergy medications (fexofenadine).
Coffee & High-Caffeine Beverages (Espresso, Energy Drinks)
Ciprofloxacin, fluvoxamine, and oral contraceptives inhibit CYP1A2, reducing caffeine clearance by 30-80% and precipitating palpitations, panic, and severe tremors. Caffeine also accelerates gastric motility, impairing bisphosphonate and thyroid absorption.
Dairy Milk, Yogurt & Calcium-Enriched Foods
Divalent calcium binds fluoroquinolone (ciprofloxacin) and tetracycline (doxycycline) antibiotics into unabsorbable ring complexes, reducing systemic antibacterial coverage by up to 90% and causing therapy failure.
Prescription & OTC Drug Interactions (DDI)
Documented pharmacological conflicts & contraindicated co-prescriptionsDietary Supplements, Herbs & Minerals (DNI)
Interactions with over-the-counter vitamins, minerals, and herbal preparationsChronotherapy & Meal Administration Protocols
Optimal absorption, meal-timing rules & GI tolerability protocolsTaking Trimethoprim alongside daily coffee, supplements, or other medications?
Add all your daily medications, foods (Dairy, Spinach, Coffee, Grapefruit), and botanicals (Ashwagandha, Curcumin, Melatonin) into the SafeStack interactive engine to run full multi-way synergy collision analysis in real time.
Data on this clinical monograph is compiled from the U.S. National Library of Medicine (MedlinePlus), openFDA Structured Product Labeling (SPL Section 7 Drug Interactions), the NIH Office of Dietary Supplements (ODS), and Krause and Mahan's Food & Nutrition Care Process.