Can You Take avanafil and grapefruit Together?
Evidence-based clinical pharmacological assessment, adverse synergy evaluation, and administration separation protocols.
Co-administering avanafil and grapefruit has documented pharmacodynamic or pharmacokinetic antagonism capable of triggering acute clinical harm. Do not combine without explicit specialist oversight.
Clinical Mechanism & Evidence Details
Inhibits intestinal CYP3A4-mediated first-pass metabolism, elevating systemic drug concentrations and increasing toxic adverse effect risks.
Alcohol may enhance gastrointestinal irritation, trigger orthostatic hypotension, or alter drug absorption kinetics.
Alcohol may enhance gastrointestinal irritation, trigger orthostatic hypotension, or alter drug absorption kinetics.
Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medicine.
Taking other supplements, foods, or medications with this pair?
Add your morning coffee, daily multivitamins, prescription pills, and dinner foods into our instant browser-based radar to check for multi-way chain reactions.
Clinical mechanism and interaction severity derived from openFDA Drug Structured Product Labeling (Section 7), NIH Office of Dietary Supplements (ODS), and NIH NCCIH clinical botanicals database.