Can You Take digoxin and licorice Together?
Evidence-based clinical pharmacological assessment, adverse synergy evaluation, and administration separation protocols.
Co-administering digoxin and licorice has documented pharmacodynamic or pharmacokinetic antagonism capable of triggering acute clinical harm. Do not combine without explicit specialist oversight.
Clinical Mechanism & Evidence Details
Glycyrrhizin inhibits renal 11-beta-HSD2, inducing pseudoaldosteronism with marked sodium retention, potassium wasting, and severe rebound hypertension.
Taking other supplements, foods, or medications with this pair?
Add your morning coffee, daily multivitamins, prescription pills, and dinner foods into our instant browser-based radar to check for multi-way chain reactions.
Clinical mechanism and interaction severity derived from openFDA Drug Structured Product Labeling (Section 7), NIH Office of Dietary Supplements (ODS), and NIH NCCIH clinical botanicals database.